The Balance of Nitric Oxide and Peroxynitrite in the Heart During Organ Preservation

The Balance of Nitric Oxide and Peroxynitrite in the Heart During Organ Preservation

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The culmination of this research was to develop and optimize a solution for long-term cardiac preservation for transplantation. This optimal solution was created using Celsior solution with the addition of several compounds including: L-arginine, sepiapterin, and BH4. This new storage solution was able to maintain hemostasis in the L-arginine/NO/ONOO- pathway by the storage time beyond 10 hours, increasing the NO/ONOO - ratio and by supporting the eNOS enzyme activity in stored hearts.75 Figure 2-1: Rat heart left ventricle (not drawn to scale). Slices of left ... Original entire heart diagram adapted from http://www.biosbcc.net/b100cardio/htm/ heartant.htm.164 . ... 88 Figure 2-4: Schematic diagram of the NO nanosensor.


Title:The Balance of Nitric Oxide and Peroxynitrite in the Heart During Organ Preservation
Author: Allyson Jill Kozak
Publisher:ProQuest - 2007
ISBN-13:

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